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The reduced payout, saving the company 180 million year, represents yield of. WELLBUTRIN XL should be used with caution in patients with hepatic impairment including mild to moderate hepatic cirrhosis and reduced frequency and or dose should be considered in patients with mild to moderate hepatic cirrhosis. Potential for Hepatotoxicity: In rats receiving large doses of bupropion chronically, there was an increase in incidence of hepatic hyperplastic nodules and hepatocellular hypertrophy. Bupropion may also be used for purposes other than those listed in this medication guide. For escitalopram, the bupropion pharmacy reviewers included 22 randomized controlled trials totaling about 4,000 participants. PRECAUTIONS General Agitation and Insomnia: substantial proportion of patients treated with WELLBUTRIN experience some degree of increased restlessness, agitation, anxiety, and insomnia, especially shortly after initiation of treatment. Set date to quit smoking during the second week of Zyban treatment.

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